The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling
JournalJournal of Diabetes Research
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AbstractThe metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors for type 2 diabetes and cardiovascular disease have been known for decades, the molecular mechanisms involved in the pathophysiology of these diseases and their interrelationship remain unclear. The LDL receptor-related protein 1 (LRP1) is a large endocytic and signaling receptor that is widely expressed in several tissues. As a member of the LDL receptor family, LRP1 is involved in the clearance of chylomicron remnants from the circulation and has been demonstrated to be atheroprotective. Recently, studies have shown that LRP1 is involved in insulin receptor trafficking and regulation and glucose metabolism. This review summarizes the role of tissue-specific LRP1 in insulin signaling and its potential role as a link between lipoprotein and glucose metabolism in diabetes. Copyright 2017 Dianaly T. Au et al.
SponsorsThis work was supported by grants from the National Heart, Lung, and Blood Institute, the National Institutes of Health (R35 HL135743 and F31 HL131293), and the American Heart Association (15SDG24470170).
Diabetes Mellitus, Type 2
Low Density Lipoprotein Receptor-Related Protein-1
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85019599272&doi=10.1155%2f2017%2f8356537&partnerID=40&md5=8f0b2b07102cd745976e003a82fd2ed3; http://hdl.handle.net/10713/10989