Seed-in-soil: Pancreatic cancer influenced by tumor microenvironment
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AbstractPancreatic ductal adenocarcinoma is a fatal malignancy with a five-year survival rate lower than 7%, and most patients dying within six months of diagnosis. The factors that contribute to the aggressiveness of the disease include, but are not limited to: late diagnosis, prompt metastasis to adjacent vital organs, poor response, and resistance to anticancer treatments. This malignancy is uniquely associated with desmoplastic stroma that accounts for 80% of tumor mass. Understanding the biology of stroma can aid the discovery of innovative strategies for eradicating this lethal cancer in the future. This review highlights the critical components in the stroma and how they interact with the cancer cells to convey the devastating tumor progression. Copyright 2017 by the authors.
SponsorsThis work was supported in part by the Interdisciplinary Collaborative Grants, Comprehensive Cancer Center, the Ohio State University to Huey-Jen Lin, as well as the University of Maryland School of Medicine and Comprehensive Cancer Center start-up fund and an AACR-Pancreatic Cancer Action Network grant to Jiayuh Lin.
Immune-suppression and microRNAs
Pancreatic ductal adenocarcinoma
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85026766018&doi=10.3390%2fcancers9070093&partnerID=40&md5=f8322b44da61b25345650aa2e1dd411f; http://hdl.handle.net/10713/10972