Commentary on biomarkers for early detection and prognosis of AKI

Abstract

Malhotra and Siew provide a detailed and highly comprehensive review of the AKI literature that carefully delineates the major categories of AKI biomarker studies. These studies can be broadly classified as addressing questions pertaining to screening or “early detection,” prognosis, and pathogenesis of human kidney injury. The authors organize the blood and urinary AKI biomarkers according to their presumed mechanisms as representing filtration, tubular function, tubular injury, or cell cycle arrest.