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dc.contributor.authorGewirtz, H.
dc.contributor.authorDilsizian, V.
dc.date.accessioned2019-09-19T18:35:46Z
dc.date.available2019-09-19T18:35:46Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85016710237&doi=10.1161%2fCIRCRESAHA.116.307898&partnerID=40&md5=7f161e0a5f30b3d5606b9ed9f9208a3b
dc.identifier.urihttp://hdl.handle.net/10713/10955
dc.description.abstractMyocardial responses to acute ischemia/reperfusion and to chronic ischemic conditions have been studied extensively at all levels of organization. These include subcellular (eg, mitochondria in vitro); intact, large animal models (eg, swine with chronic coronary stenosis); as well as human subjects. Investigations in humans have used positron emission tomographic metabolic and myocardial blood flow measurements, assessment of gene expression and anatomic description of myocardium obtained at the time of coronary artery revascularization, ventricular assist device placement, or heart transplantation. A multitude of genetic, molecular, and metabolic pathways have been identified, which may promote either myocyte survival or death or, most interestingly, both. Many of these potential mediators in both acute ischemia/reperfusion and adaptations to chronic ischemic conditions involve the mitochondria, which play a central role in cellular energy production and homeostasis. The present review is focused on operative survival mechanisms and potential myocardial viability molecular imaging targets in acute and chronic ischemia, especially those which impact mitochondrial function.en_US
dc.description.urihttps://doi.org/10.1161/CIRCRESAHA.116.307898en_US
dc.language.isoen_USen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofCirculation Research
dc.subjectfluorodeoxyglucoseen_US
dc.subjectgene programsen_US
dc.subjectmitochondriaen_US
dc.subjectmolecular imagingen_US
dc.subjectmyocardial blood flowen_US
dc.subjectmyocardiumen_US
dc.subjectoxidant stressen_US
dc.subjectrenin-angiotensin-aldosterone systemen_US
dc.titleMyocardial viability: survival mechanisms and molecular imaging targets in acute and chronic ischemiaen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/CIRCRESAHA.116.307898
dc.identifier.pmid28360350


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