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dc.contributor.authorFishman, P.S.
dc.contributor.authorFrenkel, V.
dc.date.accessioned2019-09-19T18:35:46Z
dc.date.available2019-09-19T18:35:46Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85014028211&doi=10.1007%2fs13311-017-0515-1&partnerID=40&md5=9e49f04ee9b926059f5c9bd38581e395
dc.identifier.urihttp://hdl.handle.net/10713/10954
dc.description.abstractTherapeutic ultrasound is only beginning to be applied to neurologic conditions, but the potential of this modality for a wide spectrum of brain applications is high. Engineering advances now allow sound waves to be targeted through the skull to a brain region selected with real time magnetic resonance imaging and thermography, using a commercial array of focused emitters. High intensities of sonic energy can create a coagulation lesion similar to that of older radiofrequency stereotactic methods, but without opening the skull. This has led to the recent Food and Drug Administration approval of focused ultrasound (FUS) thalamotomy for unilateral treatment of essential tremor. Clinical studies of stereotactic FUS for aspects of Parkinson's disease, chronic pain, and refractory psychiatric indications are underway, with promising results. Moderate-intensity FUS has the potential to safely open the blood-brain barrier for localized delivery of therapeutics, while low levels of sonic energy can be used as a form of neuromodulation.en_US
dc.description.urihttps://doi.org/10.1007/s13311-017-0515-1en_US
dc.language.isoen_USen_US
dc.publisherSpringer New York LLCen_US
dc.relation.ispartofNeurotherapeutics
dc.subjectblood-brain barrieren_US
dc.subjectessential tremoren_US
dc.subjectFocused ultrasounden_US
dc.subjectMRgFUSen_US
dc.subjectneuromodulationen_US
dc.subjectParkinson's diseaseen_US
dc.titleFocused Ultrasound: An Emerging Therapeutic Modality for Neurologic Diseaseen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s13311-017-0515-1
dc.identifier.pmid28244011


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