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    Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease

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    Author
    Fishman, P.S.
    Frenkel, V.
    Date
    2017
    Journal
    Neurotherapeutics
    Publisher
    Springer New York LLC
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1007/s13311-017-0515-1
    Abstract
    Therapeutic ultrasound is only beginning to be applied to neurologic conditions, but the potential of this modality for a wide spectrum of brain applications is high. Engineering advances now allow sound waves to be targeted through the skull to a brain region selected with real time magnetic resonance imaging and thermography, using a commercial array of focused emitters. High intensities of sonic energy can create a coagulation lesion similar to that of older radiofrequency stereotactic methods, but without opening the skull. This has led to the recent Food and Drug Administration approval of focused ultrasound (FUS) thalamotomy for unilateral treatment of essential tremor. Clinical studies of stereotactic FUS for aspects of Parkinson's disease, chronic pain, and refractory psychiatric indications are underway, with promising results. Moderate-intensity FUS has the potential to safely open the blood-brain barrier for localized delivery of therapeutics, while low levels of sonic energy can be used as a form of neuromodulation.
    Keyword
    blood-brain barrier
    essential tremor
    Focused ultrasound
    MRgFUS
    neuromodulation
    Parkinson's disease
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014028211&doi=10.1007%2fs13311-017-0515-1&partnerID=40&md5=9e49f04ee9b926059f5c9bd38581e395; http://hdl.handle.net/10713/10954
    ae974a485f413a2113503eed53cd6c53
    10.1007/s13311-017-0515-1
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