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    Remodeling KRAS

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    Author
    Deredge, D.J.
    Wintrode, P.L.
    Date
    2017
    Journal
    Structure
    Publisher
    Cell Press
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.str.2017.08.012
    Abstract
    Mutations in members of the RAS family of small GTPases have been associated with numerous human cancers. However, RAS family members are notoriously difficult to target. In this issue of Structure, Lu et al. (2017) examine the effects of two compounds with distinct chemical scaffolds on the structure and dynamics of an oncogenic KRAS mutant, thus highlighting the usefulness of HDX-MS for drug development.
    Keyword
    KRAS mutation
    RAS proteins
    HDX-MS
    Cancer
    Humans
    Monomeric GTP-Binding Proteins
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028695525&doi=10.1016%2fj.str.2017.08.012&partnerID=40&md5=4e79059861be93671e9452b3d6b89034; http://hdl.handle.net/10713/10950
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.str.2017.08.012
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    UMB Open Access Articles 2017

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