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    Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease

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    Author
    Blanchard, T.G.
    Czinn, S.J.
    Date
    2017
    Journal
    Pediatric Research
    Publisher
    Nature Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/pr.2016.199
    Abstract
    Establishment of Helicobacter pylori infection as an etiologic agent of peptic ulcer disease and other gastric pathologies marked a revolution in gastroenterology which spurred an enormous interest in gastric physiology and immunology research. The association was soon also demonstrated in children as well. Application of antimicrobial therapies have proven remarkably efficacious in eradicating H. pylori and curing pediatric patients of duodenal ulcers as well as gastritis, negating a lifetime of ineffective therapy and life-threatening disease. Countries with high H. pylori prevalence and where H. pylori associated gastric cancer remains a primary cause of death due to cancer however would benefit from childhood vaccination. Studies in rodents and humans utilizing oral vaccination with bacterial exotoxin adjuvants demonstrated potential for limiting H. pylori colonization in the stomach. Almost 25 y of vaccine research recently culminated in a phase III clinical trial of over 4,000 children aged 6-15 y old to test an oral vaccine consisting of the H. pylori urease B subunit genetically fused to the E. coli heat labile toxin. Vaccination was demonstrated to have an efficacy of over 70%. Vaccination may now serve as an effective strategy to significantly reduce H. pylori associated disease in children throughout the world.
    Keyword
    Bacterial Vaccines--therapeutic use
    Gastritis--prevention & control
    Helicobacter Infections--prevention & control
    Helicobacter pylori
    Peptic Ulcer--prevention & control
    Stomach Neoplasms--prevention & control
    Vaccination
    Child
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009830041&doi=10.1038%2fpr.2016.199&partnerID=40&md5=f136a8ff033c80809758d4636e96ae44; http://hdl.handle.net/10713/10937
    ae974a485f413a2113503eed53cd6c53
    10.1038/pr.2016.199
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    UMB Open Access Articles 2017

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