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    Location, Location, Location: Microglia Are Where They Live

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    Author
    McCarthy, M.M.
    Date
    2017
    Journal
    Neuron
    Publisher
    Cell Press
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.neuron.2017.07.005
    Abstract
    A deep dive into microglia form and function reveals startling regional heterogeneity in number, morphology, activity, and transcriptomics in nuclei relevant to motor control and motivation (De Biase et al., 2017). Differences appear 2 weeks after birth, and depletion and recolonization in adulthood recapitulate the original phenotype, implicating local environment as mediators of microglial phenotype. A deep dive into microglia form and function reveals startling regional heterogeneity in number, morphology, activity, and transcriptomics in nuclei relevant to motor control and motivation (De Biase et al.). Differences appear 2 weeks after birth, and depletion and recolonization in adulthood recapitulate the original phenotype, implicating local environment as mediators of microglial phenotype.
    Keyword
    Microglia
    Environment
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029561795&doi=10.1016%2fj.neuron.2017.07.005&partnerID=40&md5=40c7d4adc02a1c257f74ea784887826b; http://hdl.handle.net/10713/10924
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuron.2017.07.005
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