• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    STUB1 suppresseses tumorigenesis and chemoresistance through antagonizing YAP1 signaling

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Tang, D.-E.
    Dai, Y.
    Lin, L-W.
    Date
    2019
    Journal
    Cancer Science
    Publisher
    Blackwell Publishing Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1111/cas.14166
    Abstract
    Yes-associated protein (YAP) is a component of the canonical Hippo signaling pathway that is known to play essential roles in modulating organ size, development, and tumorigenesis. Activation or upregulation of YAP1, which contributes to cancer cell survival and chemoresistance, has been verified in different types of human cancers. However, the molecular mechanism of YAP1 upregulation in cancer is still unclear. Here we report that the E3 ubiquitin ligase STUB1 ubiquitinates and destabilizes YAP1, thereby inhibiting cancer cell survival. Low levels of STUB1 expression were correlated with increased protein levels of YAP1 in human gastric cancer cell lines and patient samples. Moreover, we revealed that STUB1 ubiquitinates YAP1 at the K280 site by K48-linked polyubiquitination, which in turn increases YAP1 turnover and promotes cellular chemosensitivity. Overall, our study establishes YAP1 ubiquitination and degradation mediated by the E3 ligase STUB1 as an important regulatory mechanism in gastric cancer, and provides a rationale for potential therapeutic interventions. Copyright 2019 The Authors.
    Sponsors
    This work was supported by the National Natural Science Foundation of China (31700795), the Science & Technology Planning Project of Guangdong Province of China (2017B020209001), the Natural Science Foundation of Guangdong Province of China (2017A030310629), the Natural Science Foundation for Young Scientists of China (Grant No. 31700795), and the Science & Technology Plan of Shenzhen (JCYJ20170307095606266).
    Keyword
    chemoresistance
    gastric cancer
    STUB1
    ubiquitination
    YAP1
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071946895&doi=10.1111%2fcas.14166&partnerID=40&md5=10f0d07741b89a8bf21cacd32ed17fac; http://hdl.handle.net/10713/10858
    ae974a485f413a2113503eed53cd6c53
    10.1111/cas.14166
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.