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dc.contributor.authorKapadia, B.B.
dc.contributor.authorGartenhaus, R.B.
dc.date.accessioned2019-09-14T14:28:33Z
dc.date.available2019-09-14T14:28:33Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071760673&doi=10.1158%2f1535-7163.MCT-19-0307&partnerID=40&md5=e17949ee1b8ca8e80e77d79750990e9c
dc.identifier.urihttp://hdl.handle.net/10713/10830
dc.description.abstractCancer cells revamp the regulatory processes that control translation to induce tumor-specific translational programs that can adapt to a hostile microenvironment as well as withstand anticancer therapeutics. Translational initiation has been established as a common downstream effector of numerous deregulated signaling pathways that together culminate in prooncogenic expression. Other mechanisms, including ribosomal stalling and stress granule assembly, also appear to be rewired in the malignant phenotype. Therefore, better understanding of the underlying perturbations driving oncogenic translation in the transformed state will provide innovative therapeutic opportunities. This review highlights deubiquitinating enzymes that are activated/dysregulated in hematologic malignancies, thereby altering the translational output and contributing to tumorigenesis.en_US
dc.description.sponsorshipR.B. Gartenhaus is supported by grant funding in part by a Merit Review Award from the Department of Veterans Affairs and NIH (RO1CA164311).en_US
dc.description.urihttps://doi.org/10.1158/1535-7163.MCT-19-0307en_US
dc.language.isoen-USen_US
dc.publisherAmerican Association for Cancer Research Inc.en_US
dc.relation.ispartofMolecular Cancer Therapeutics
dc.subject.meshDeubiquitinating Enzymesen_US
dc.subject.meshOncogenesisen_US
dc.titleDubbing down translation: The functional interaction of deubiquitinases with the translational machineryen_US
dc.typeArticleen_US
dc.identifier.doi10.1158/1535-7163.MCT-19-0307
dc.identifier.pmid31481479


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