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dc.contributor.authorXu, H.H.K.
dc.contributor.authorWeir, M.D.
dc.contributor.authorTiwari, S.K.en_US
dc.date.accessioned2019-09-14T14:28:32Z
dc.date.available2019-09-14T14:28:32Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071495381&doi=10.1038%2fs41598-019-48666-4&partnerID=40&md5=73f33b024b808d57b62f530ee48c538d
dc.identifier.urihttp://hdl.handle.net/10713/10824
dc.description.abstractPersisting apical periodontitis is a primary reason for multiple intervention in root canal. Persisting bacteria in root canal is related with the persisting infection. Despite the advancement in treatment strategies the persisting infection is a major challenge for endodontist. Here we tested two newly developed quaternary ammonium methacrylates (QAMs) against endodontic bacteria and their biofilms. Their antibacterial and antibiofilm efficiency were compared with chlorhexidine (CHX) and sodium hypochlorite (NaOCl). We measured the MIC, MBC and MBIC of DMADDM and DMAHDM respectively. We also detected the ratio of live/dead bacteria and bacterial composition in the biofilms treated by DMADDM and DMAHDM. We found that DMADDM and DMAHDM could inhibit the growth of bacteria and biofilms formation. The result showed that novel QAMs were remarkably efficient than CHX against biofilms. In addition, we found that Streptococcus gordonii (S. gordonii) and Enterococcus faecalis (E. faecalis) were frequent isolates after treatment with antimicrobial compounds. Copyright 2019, The Author(s).en_US
dc.description.sponsorshipThis study was supported by the National Key Research Program of China (2017YFC0840100 and 2017YFC0840107 to L.C.); National Natural Science Foundation of China grant (81430011 to X.Z. and 81870759 to L.C.); International Science and Technology Cooperation Program of Sichuan Province (2017HH0008 to L.C.); Innovative Research Team Program of Sichuan Province to L.C.en_US
dc.description.urihttps://doi.org/10.1038/s41598-019-48666-4en_US
dc.language.isoen-USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reports
dc.subjectquaternary ammonium methacrylatesen_US
dc.subject.meshPeriapical Periodontitis--prevention & controlen_US
dc.subject.meshRoot Canal Therapyen_US
dc.titleThe inhibitory effect of quaternary ammonium salt on bacteria in root canalen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-019-48666-4
dc.identifier.pmid31462657


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