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    The Use of Radiation Therapy for the Treatment of Malignant Pleural Mesothelioma: Expert Opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Re

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    Author
    Gomez, D.R.
    Rimner, A.
    Simone, C.B.
    Date
    2019
    Journal
    Journal of Thoracic Oncology
    Publisher
    Elsevier Inc
    Type
    Article
    
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    https://doi.org/10.1016/j.jtho.2019.03.030
    Abstract
    Introduction: Detailed guidelines regarding the use of radiation therapy for malignant pleural mesothelioma (MPM) are currently lacking because of the rarity of the disease, the wide spectrum of clinical presentations, and the paucity of high-level data on individual treatment approaches. Methods: In March 2017, a multidisciplinary meeting of mesothelioma experts was cosponsored by the U.S. National Cancer Institute, International Association for the Study of Lung Cancer Research, and Mesothelioma Applied Research Foundation. Among the outcomes of this conference was the foundation of detailed, multidisciplinary consensus guidelines. Results: Here we present consensus recommendations on the use of radiation therapy for MPM in three discrete scenarios: (1) hemithoracic radiation therapy to be used before or after extrapleural pneumonectomy; (2) hemithoracic radiation to be used as an adjuvant to lung-sparing procedures (i.e., without pneumonectomy); and (3) palliative radiation therapy for focal symptoms caused by the disease. We discuss appropriate simulation techniques, treatment volumes, dose fractionation regimens, and normal tissue constraints. We also assess the role of particle beam therapy, specifically, proton beam therapy, for MPM. Conclusion: The recommendations provided in this consensus statement should serve as important guidelines for developing future clinical trials of treatment approaches for MPM.
    Keyword
    Consensus guidelines
    Mesothelioma
    Radiation therapy
    Treatment recommendations
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067574879&doi=10.1016%2fj.jtho.2019.03.030&partnerID=40&md5=cad4077dc69d010c8adaaa0a297139c6; http://hdl.handle.net/10713/10802
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jtho.2019.03.030
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