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dc.contributor.authorKollisch-Singule, M.
dc.contributor.authorAndrews, P.
dc.contributor.authorSatalin, J.
dc.date.accessioned2019-09-13T17:02:32Z
dc.date.available2019-09-13T17:02:32Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065070751&doi=10.1183%2f16000617.0126-2018&partnerID=40&md5=b9d5af79e4f68d4e7c7f8b90c8e32982
dc.identifier.urihttp://hdl.handle.net/10713/10800
dc.description.abstractAirway pressure release ventilation (APRV) is a ventilator mode that has previously been considered a rescue mode, but has gained acceptance as a primary mode of ventilation. In clinical series and experimental animal models of extrapulmonary acute respiratory distress syndrome (ARDS), the early application of APRV was able to prevent the development of ARDS. Recent experimental evidence has suggested mechanisms by which APRV, using the time-controlled adaptive ventilation (TCAV) protocol, may reduce lung injury, including: 1) an improvement in alveolar recruitment and homogeneity; 2) reduction in alveolar and alveolar duct micro-strain and stress-risers; 3) reduction in alveolar tidal volumes; and 4) recruitment of the chest wall by combating increased intra-abdominal pressure. This review examines these studies and discusses our current understanding of the pleiotropic mechanisms by which TCAV protects the lung. APRV set according to the TCAV protocol has been misunderstood and this review serves to highlight the various protective physiological and mechanical effects it has on the lung, so that its clinical application may be broadened.en_US
dc.description.sponsorshipFunding was received from the U.S. Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute (R01 HL131143).en_US
dc.description.urihttps://doi.org/10.1183/16000617.0126-2018en_US
dc.language.isoen-USen_US
dc.publisherEuropean Respiratory Societyen_US
dc.relation.ispartofEuropean Respiratory Review
dc.subject.meshContinuous Positive Airway Pressureen_US
dc.subject.meshVenilator-Induced Lung Injury--prevention & controlen_US
dc.titleThe time-controlled adaptive ventilation protocol: Mechanistic approach to reducing ventilator-induced lung injuryen_US
dc.typeArticleen_US
dc.identifier.doi10.1183/16000617.0126-2018
dc.identifier.pmid30996041


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