The mechanical role of a cytoskeletal protein, Synemin, in bone, heart and skeletal muscle
JournalAIP Conference Proceedings
PublisherAmerican Institute of Physics Inc.
MetadataShow full item record
AbstractIntermediate filaments (IFs) represent a major cytoskeletal network contributing to force transmission, cell shape and structure, adhesion and motility, subcellular scaffolding and tissue resilience, thereby modulating a range of cellular activities. Life-threatening disorders associated with IF mutations have pushed investigations to study IFs of mammalian cells in culture and in vivo. Keratin and Lamin related disorders, Desmin-related myopathy, Muscular Dystrophies, Alexander disease are just examples of pathologies related to IFs. Synemin, a type IV IF has become a target for research since its AKAP role in the heart was reported. Here we summarize our results with Synemin "knock-out" mice showing that Synemin plays a significant role in skeletal and cardiac muscle, leading to a mild skeletal myopathy and a mixed cardiomyopathy. We also report an important role of Synemin, with the absence of Synemin leading to osteopenia. Copyright 2019 Author(s).
SponsorsThis work was supported partially by Grants R01-AR-063631 (J. P. Stains) and R01-AR-055928 (R. J. Bloch) from the NIH, and UNAM-PAPIIT IA207818 (K.P.Garcia-Pelagio).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85064880544&doi=10.1063%2f1.5095923&partnerID=40&md5=2ac6d822f19acc3fa6312987f7d8eea9; http://hdl.handle.net/10713/10790