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    The mechanical role of a cytoskeletal protein, Synemin, in bone, heart and skeletal muscle

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    Author
    Buo, A.M.
    Chen, L.
    García-Pelagio, K.P.
    Date
    2019
    Journal
    AIP Conference Proceedings
    Publisher
    American Institute of Physics Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1063/1.5095923
    Abstract
    Intermediate filaments (IFs) represent a major cytoskeletal network contributing to force transmission, cell shape and structure, adhesion and motility, subcellular scaffolding and tissue resilience, thereby modulating a range of cellular activities. Life-threatening disorders associated with IF mutations have pushed investigations to study IFs of mammalian cells in culture and in vivo. Keratin and Lamin related disorders, Desmin-related myopathy, Muscular Dystrophies, Alexander disease are just examples of pathologies related to IFs. Synemin, a type IV IF has become a target for research since its AKAP role in the heart was reported. Here we summarize our results with Synemin "knock-out" mice showing that Synemin plays a significant role in skeletal and cardiac muscle, leading to a mild skeletal myopathy and a mixed cardiomyopathy. We also report an important role of Synemin, with the absence of Synemin leading to osteopenia. Copyright 2019 Author(s).
    Sponsors
    This work was supported partially by Grants R01-AR-063631 (J. P. Stains) and R01-AR-055928 (R. J. Bloch) from the NIH, and UNAM-PAPIIT IA207818 (K.P.Garcia-Pelagio).
    Keyword
    Synemin
    Intermediate Filaments
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064880544&doi=10.1063%2f1.5095923&partnerID=40&md5=2ac6d822f19acc3fa6312987f7d8eea9; http://hdl.handle.net/10713/10790
    ae974a485f413a2113503eed53cd6c53
    10.1063/1.5095923
    Scopus Count
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    UMB Open Access Articles 2019

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