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dc.contributor.authorLiu, Q.
dc.contributor.authorYang, Y.
dc.contributor.authorGe, S.
dc.date.accessioned2019-09-13T16:42:04Z
dc.date.available2019-09-13T16:42:04Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068258956&doi=10.1111%2fijd.14550&partnerID=40&md5=f0fa9dd75f50986a8c643d6c46c9feeb
dc.identifier.urihttp://hdl.handle.net/10713/10757
dc.description.abstractBackground: Henoch–Schonlein purpura (HSP) is a systemic small vessel vasculitis that is mainly caused by IgA1-type immune complex deposition. Advanced oxidation protein products (AOPPs) are specific markers of protein oxidation. Objective: To explore the role of AOPPs in the pathogenesis of HSP. Methods: There are 51 HSP patients who were divided into four subgroups: (i) skin type – 20 cases; (ii) joint type – 8 cases; (iii) abdominal type – 12 cases; (iv) renal type – 11 cases; and 18 healthy volunteers were enrolled as controls. The serum levels of AOPPs and Gd-IgA1 were quantified by an HAA-lectin-based ELISA. The Cosmc mRNA expression in peripheral B lymphocytes was measured by RT-PCR. Results: 1. Advanced oxidation protein products in different subgroups of HSP patients are all higher than the controls, while the renal-type subgroup is the highest and the skin-type subgroup is the lowest. 2. Spearman correlation analysis shows that: (i) AOPPs and Gd-IgA1 in HSP patients are positively correlated; both of them are positively correlated with the disease severity scores; (ii) AOPPs are negatively correlated with the relative expression value (RQ) of Cosmc mRNA. Conclusion: Advanced oxidation protein products play an important role in the pathogenesis of HSP, especially in renal-type patients. © 2019 The Authors.en_US
dc.description.urihttps://doi.org/10.1111/ijd.14550en_US
dc.language.isoen-USen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofInternational Journal of Dermatology
dc.subjectCosmcen_US
dc.subjectgalactose-deficient IgA1en_US
dc.subjectHenoch-Schonlein purpuraen_US
dc.subjectperipheral B lymphocytesen_US
dc.subjectserum AOPPsen_US
dc.titleSerum level of advanced oxidation protein products (AOPPs) in patients with Henoch–Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expressionen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/ijd.14550


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