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dc.contributor.authorWang, C.
dc.contributor.authorPan, Y.-H.
dc.contributor.authorWang, Y.
dc.date.accessioned2019-09-13T16:42:04Z
dc.date.available2019-09-13T16:42:04Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065249278&doi=10.1186%2fs13041-019-0461-4&partnerID=40&md5=c277884ef3122fa2abacd2984de3ce51
dc.identifier.urihttp://hdl.handle.net/10713/10755
dc.description.abstractResults of recent genome-wide association studies (GWAS) and whole genome sequencing (WGS) highlighted type II cadherins as risk genes for autism spectrum disorders (ASD). To determine whether these cadherins may be linked to the morphogenesis of ASD-relevant brain regions, in situ hybridization (ISH) experiments were carried out to examine the mRNA expression profiles of two ASD-associated cadherins, Cdh9 and Cdh11, in the developing cerebellum. During the first postnatal week, both Cdh9 and Cdh11 were expressed at high levels in segregated sub-populations of Purkinje cells in the cerebellum, and the expression of both genes was declined as development proceeded. Developmental expression of Cdh11 was largely confined to dorsal lobules (lobules VI/VII) of the vermis as well as the lateral hemisphere area equivalent to the Crus I and Crus II areas in human brains, areas known to mediate high order cognitive functions in adults. Moreover, in lobules VI/VII of the vermis, Cdh9 and Cdh11 were expressed in a complementary pattern with the Cdh11-expressing areas flanked by Cdh9-expressing areas. Interestingly, the high level of Cdh11 expression in the central domain of lobules VI/VII was correlated with a low level of expression of the Purkinje cell marker calbindin, coinciding with a delayed maturation of Purkinje cells in the same area. These findings suggest that these two ASD-associated cadherins may exert distinct but coordinated functions to regulate the wiring of ASD-relevant circuits in the cerebellum. Copyright 2019 The Author(s).en_US
dc.description.sponsorshipThis study was supported by Hussman Foundation grant #HIAS15006. XY was funded by the National Science Foundation of China (31771116, 31871501).en_US
dc.description.urihttps://doi.org/10.1186/s13041-019-0461-4en_US
dc.language.isoen-USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofMolecular Brain
dc.subjectASDen_US
dc.subjectCdh11en_US
dc.subjectCdh9en_US
dc.subjectCerebellumen_US
dc.subjectDevelopmenten_US
dc.subjectIn situ hybridizationen_US
dc.titleSegregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellumen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s13041-019-0461-4
dc.identifier.pmid31046797


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