• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Utilization patterns and drug budget impact of the angiotensin II receptor blockers

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Find Full text
    Author
    Blak, Betina Thordal
    Advisor
    Mullins, C. Daniel
    Date
    2006
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    The Angiotensin II Receptor Blockers (ARBs) are the latest drug class approved for hypertension treatment. The aims of this study were: (1) to identify patient characteristics associated with ARB use over time when compared to each of the other therapeutic classes approved for hypertension treatment, and (2) to evaluate the drug budget impact surrounding the introduction of ARBs in the United Kingdom (U.K.).;Data sources included The Health Improvement Network database, an electronic medical record dataset of patients seen by general practitioners in the U.K., and the Chemist & Druggist monthly drug price list from January, 2005. Immediately after the first ARB introduction (1995--1997), patients with high blood pressure readings and patients seen by a Cardiologist were more likely to receive prescriptions for ARBs than other antihypertensive classes. This did not persist for the more recent time period comprising 2001--2003. Over time, prescriptions for antihypertensive drugs for patients with diabetes shifted away from all classes, except the Angiotensin Converting Enzyme inhibitor class (ACEi), towards ARB treatment. For patients with heart failure, there was a statistically significantly shift away from prescribing ARBs towards the Beta Blocker and "Other" classes. In general, patients with diabetes or heart failure were more frequently prescribed ACEi than ARB therapy.;Among prescriptions for drugs approved for hypertension treatment, ARB prescription frequency increased from 0.04% in 1995 to 6.57% in 2004. Expenditures for drugs approved for hypertension treatment were estimated at £465,862,416 in 1995 and £1,458,268,104 in 2004 (2005 British Pounds values). This represents a 213% real rate of increase. Of the increase in average antihypertensive drug expenditures per prescription identified from 1995 to 2004, the use of ARBs accounted for only 5.8% to 9.3%. A shift towards more expensive treatments, increase in treatment prevalence and increasing use of more prescriptions per patient over time all contributed to the increased antihypertensive drug budget.;This study highlights that the ARBs are being used with caution in the U.K. and that the antihypertensive drug budget increase during the first 10 years of the ARB market life is explained by several factors besides ARB use.
    Description
    University of Maryland, Baltimore. Pharmaceutical Health Services Research. Ph.D. 2006
    Keyword
    Health Sciences, Pharmacy
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/1075
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Pharmacy

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.