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dc.contributor.authorKim, H.J.
dc.contributor.authorGreenspan, J.D.
dc.contributor.authorOhrbach, R.
dc.date.accessioned2019-09-13T16:42:02Z
dc.date.available2019-09-13T16:42:02Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85064485872&doi=10.1371%2fjournal.pone.0215534&partnerID=40&md5=1b6fef911b2e6215982f58821f018dad
dc.identifier.urihttp://hdl.handle.net/10713/10735
dc.description.abstractThis study evaluated the contributions of psychological status and cardiovascular responsiveness to racial/ethnic differences in experimental pain sensitivity. The baseline measures of 3,159 healthy individuals-non-Hispanic white (NHW): 1,637, African-American (AA): 1,012, Asian: 299, and Hispanic: 211-from the OPPERA prospective cohort study were used. Cardiovascular responsiveness measures and psychological status were included in structural equation modeling based mediation analyses. Pain catastrophizing was a significant mediator for the associations between race/ethnicity and heat pain tolerance, heat pain ratings, heat pain aftersensations, mechanical cutaneous pain ratings and aftersensations, and mechanical cutaneous pain temporal summation for both Asians and AAs compared to NHWs. HR/MAP index showed a significant inconsistent (mitigating) mediating effect on the association between race/ethnicity (AAs vs. NHWs) and heat pain tolerance. Similarly, coping inconsistently mediated the association between race/ethnicity and mechanical cutaneous pain temporal summation in both AAs and Asians, compared to NHWs. The factor encompassing depression, anxiety, and stress was a significant mediator for the associations between race/ethnicity (Asians vs. NHWs) and heat pain aftersensations. Thus, while pain catastrophizing mediated racial/ethnic differences in many of the QST measures, the psychological and cardiovascular mediators were distinctly restrictive, signifying multiple independent mechanisms in racial/ethnic differences in pain. Copyright 2019 Kim et al.en_US
dc.description.urihttps://doi.org/10.1371/journal.pone.0215534en_US
dc.language.isoen-USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONE
dc.subjectexperimental pain sensitivityen_US
dc.subject.meshCardiovascular diseasesen_US
dc.subject.meshPainen_US
dc.subject.meshPsychologyen_US
dc.subject.meshRace Factorsen_US
dc.titleRacial/ethnic differences in experimental pain sensitivity and associated factors - Cardiovascular responsiveness and psychological statusen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0215534
dc.identifier.pmid30998733


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