Show simple item record

dc.contributor.authorBlois, S.M.
dc.contributor.authorDveksler, G.
dc.contributor.authorVasta, G.R.
dc.date.accessioned2019-09-13T16:42:01Z
dc.date.available2019-09-13T16:42:01Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068546839&doi=10.3389%2ffimmu.2019.01166&partnerID=40&md5=1e2e36a21db2ed4f35c536669e78f559
dc.identifier.urihttp://hdl.handle.net/10713/10724
dc.description.abstractGalectins are a phylogenetically conserved family of soluble ?-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders. Copyright Copyright 2019 Blois, Dveksler, Vasta, Freitag, Blanchard and Barrientos.en_US
dc.description.urihttps://doi.org/10.3389/fimmu.2019.01166en_US
dc.language.isoen-USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Immunology
dc.subjectGalectinsen_US
dc.subjectGlycansen_US
dc.subjectPlacentationen_US
dc.subjectPreeclampsiaen_US
dc.subjectPregnancyen_US
dc.titlePregnancy galectinology: Insights into a complex network of glycan binding proteinsen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fimmu.2019.01166
dc.identifier.pmid31231368


This item appears in the following Collection(s)

Show simple item record