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dc.contributor.authorXin, W.
dc.contributor.authorMironova, Y.A.
dc.contributor.authorShen, H.
dc.date.accessioned2019-09-13T16:41:59Z
dc.date.available2019-09-13T16:41:59Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065392864&doi=10.1016%2fj.celrep.2019.04.094&partnerID=40&md5=445e0a1756a16b0a7c9feea021d37e39
dc.identifier.urihttp://hdl.handle.net/10713/10701
dc.description.abstractGlutamate has been implicated in a wide range of brain pathologies and is thought to be metabolized via the astrocyte-specific enzyme glutamine synthetase (GS). We show here that oligodendrocytes, the myelinating glia of the central nervous system, also express high levels of GS in caudal regions like the midbrain and the spinal cord. Selective removal of oligodendrocyte GS in mice led to reduced brain glutamate and glutamine levels and impaired glutamatergic synaptic transmission without disrupting myelination. Furthermore, animals lacking oligodendrocyte GS displayed deficits in cocaine-induced locomotor sensitization, a behavior that is dependent on glutamatergic signaling in the midbrain. Thus, oligodendrocytes support glutamatergic transmission through the actions of GS and may represent a therapeutic target for pathological conditions related to brain glutamate dysregulation. Xin et al. show that mature oligodendrocytes, the myelinating cells of the brain, express the glutamine-synthesizing enzyme glutamine synthetase (GS). Oligodendrocyte-specific GS deletion does not impair myelination but disrupts neuronal glutamatergic transmission, thus demonstrating a myelin-independent role for oligodendrocytes in supporting glutamate signaling in the brain. Copyright 2019 The Authorsen_US
dc.description.urihttps://doi.org/10.1016/j.celrep.2019.04.094en_US
dc.language.isoen-USen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofCell Reports
dc.subjectcocaineen_US
dc.subjectgliaen_US
dc.subjectglutamateen_US
dc.subjectglutamineen_US
dc.subjectglutamine synthetaseen_US
dc.subjectmidbrainen_US
dc.subjectoligodendrocyteen_US
dc.subjecttransmissionen_US
dc.titleOligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetaseen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.celrep.2019.04.094
dc.identifier.pmid31116973


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