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dc.contributor.authorWhitman, I.R.
dc.contributor.authorVittinghoff, E.
dc.contributor.authorDeFilippi, C.R.
dc.date.accessioned2019-09-13T16:41:59Z
dc.date.available2019-09-13T16:41:59Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85063713152&doi=10.1161%2fJAHA.118.010868&partnerID=40&md5=46d59b8ed0de597b42441f9561826f98
dc.identifier.urihttp://hdl.handle.net/10713/10700
dc.description.abstractBackground-Blacks harbor more cardiovascular risk factors than whites, but experience less atrial fibrillation (AF). Conversely, whites may have a lower risk of heart failure (CHF). N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are higher in whites, predict incident AF, and have diuretic effects in the setting of increased ventricular diastolic pressures, potentially providing a unifying explanation for these racial differences. Methods and Results-We used data from the CHS (Cardiovascular Health Study) to determine the degree to which baseline NTproBNP levels mediate the relationships between race and incident AF and CHF by comparing beta estimates between models with and without NT-proBNP. The ARIC (Atherosclerosis Risk in Communities) study was used to assess reproducibility. Among 4731 CHS (770 black) and 12 418 ARIC (3091 black) participants, there were 1277 and 1253 incident AF events, respectively. Whites had higher baseline NT-proBNP (CHS: 40% higher than blacks; 95% CI, 29-53; ARIC: 39% higher; 95% CI, 33-46) and had a greater risk of incident AF compared with blacks (CHS: adjusted hazard ratio, 1.60; 95% CI, 1.31-1.93; ARIC: hazard ratio, 1.93; 95% CI, 1.57-2.27). NT-proBNP levels explained a significant proportion of the racial difference in AF risk (CHS: 36.2%; 95% CI, 23.2- 69.2%; ARIC: 24.6%; 95% CI, 14.8-39.6%). Contrary to our hypothesis, given an increased risk of CHF among whites in CHS (adjusted hazard ratio, 1.20; 95% CI, 1.05-1.47) and the absence of a significant association between race and CHF in ARIC (adjusted hazard ratio, 1.07; 95% CI, 0.94-1.23), CHF-related mediation analyses were not performed. Conclusions-A substantial portion of the relationship between race and AF was statistically explained by baseline NT-proBNP levels. No consistent relationship between race and CHF was observed. Copyright 2019 The Authors.en_US
dc.description.sponsorshipThis research was supported by contracts HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086 and grants U01HL080295 and U01HL130114 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS).en_US
dc.description.urihttps://doi.org/10.1161/JAHA.118.010868en_US
dc.language.isoen-USen_US
dc.publisherAmerican Heart Association Inc.en_US
dc.relation.ispartofJournal of the American Heart Association
dc.subjectAtrial fibrillation arrhythmiaen_US
dc.subjectCongestive heart failureen_US
dc.subjectMechanismsen_US
dc.subjectMediationen_US
dc.subjectNatriuretic peptideen_US
dc.subjectNT-proBNPen_US
dc.titleNT-proBNP as a mediator of the racial difference in incident atrial fibrillation and heart failureen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/JAHA.118.010868
dc.identifier.pmid30912456


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