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    Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency

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    Author
    Zheng, Y.
    Liu, C.
    Li, Y.
    Date
    2019
    Journal
    Biology of reproduction
    Publisher
    Oxford
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/biolre/ioy245
    Abstract
    The mechanism underlying premature ovarian insufficiency remains incompletely understood. Here we report that mice with Per1m/m; Per2m/m double mutations display a decrease in female fertility starting approximately at 20 weeks old, with significantly less pups born from 32 weeks old onwards. Histological analysis revealed that a significant reduction of ovarian follicles was observed in the Per1/Per2 mutants compared with the littermate controls examined at 26 and 52 weeks old, while the difference was not statistically significant between the two groups at 3 and 8 weeks old. We further showed that vascular development including the ovarian follicle associated vascular growth appeared normal in the Per1/Per2 mutant mice, although clock genes were reported to regulate angiogenesis in zebrafish. The findings imply that loss-of-function mutations with Per1/Per2 result in a premature depletion of ovarian follicle reserve leading to the decline of reproductive capacity. Copyright The Author(s) 2018.
    Keyword
    knockout mouse
    ovarian follicle
    ovarian insufficiency
    PER1
    PER2
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068538072&doi=10.1093%2fbiolre%2fioy245&partnerID=40&md5=23b8069535ebb610af511418462a2486; http://hdl.handle.net/10713/10679
    ae974a485f413a2113503eed53cd6c53
    10.1093/biolre/ioy245
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    UMB Open Access Articles 2019

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