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    Knowns and unknowns of assaying antibody-dependent cell-mediated cytotoxicity against HIV-1

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    Author
    Lewis, G.K.
    Ackerman, M.E.
    Scarlatti, G.
    Date
    2019
    Journal
    Frontiers in Immunology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fimmu.2019.01025
    Abstract
    It is now well-accepted that Fc-mediated effector functions, including antibody-dependent cellular cytotoxicity (ADCC), can contribute to vaccine-elicited protection as well as post-infection control of HIV viremia. This picture was derived using a wide array of ADCC assays, no two of which are strictly comparable, and none of which is qualified at the clinical laboratory level. An earlier comparative study of assay protocols showed that while data from different ADCC assay formats were often correlated, they remained distinct in terms of target cells and the epitopes and antigen(s) available for recognition by antibodies, the effector cells, and the readout of cytotoxicity. This initial study warrants expanded analyses of the relationships among all current assay formats to determine where they detect overlapping activities and where they do not. Here we summarize knowns and unknowns of assaying ADCC against HIV-1. Copyright Copyright 2019 Lewis, Ackerman, Scarlatti, Moog, Robert-Guroff, Kent, Overbaugh, Reeves, Ferrari and Thyagarajan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Keyword
    ADCC-antibody dependent cellular cytotoxicity
    Antibodies
    Effector function
    Fc receptor
    HIV-human immunodeficiency virus
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067010419&doi=10.3389%2ffimmu.2019.01025&partnerID=40&md5=4f94a60c64b3dfa8fee731284c3e5392; http://hdl.handle.net/10713/10672
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2019.01025
    Scopus Count
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    UMB Open Access Articles 2019

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