In search of a rodent model of placebo analgesia in chronic orofacial neuropathic pain
JournalNeurobiology of Pain
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AbstractAll treatments are given in a context, suggesting that conditioning cues may significantly influence therapeutic outcomes. We tested the hypothesis that context affects placebo analgesia in rodents. To produce neuropathic pain in rats, we performed chronic constriction injury of the infraorbital nerve. We then treated the rats daily, over a seven day period, with injections of either fentanyl or saline, with or without associated conditioning cues; a fourth group received no treatment. On the eighth day, we replaced fentanyl with saline to test for conditioned placebo analgesia. We tested the effects of treatment by measuring sensitivity to mechanical stimuli and grimace scale scores. We found no significant differences in either of these outcomes among the four experimental groups. These findings suggest that chronic, neuropathic pain in rats may not be susceptible to placebo analgesia.
SponsorsResearch reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health grant R01NS099245 and the National Institute of Dental and Craniofacial Research grant R01DE025946.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065896392&doi=10.1016%2fj.ynpai.2019.100033&partnerID=40&md5=fa7f41703c6f9a882730e46c022f19cc; http://hdl.handle.net/10713/10662