• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2019
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2019
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Hsp60 as a novel target in IBD management: A prospect

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Cappello, F.
    Mazzola, M.
    Jurjus, A.
    Date
    2019
    Journal
    Frontiers in Pharmacology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fphar.2019.00026
    Abstract
    Inflammatory bowel disease (IBD) encompasses various pathological conditions similar but distinct that share a multifactorial etiology, including involvement of the intestinal barrier function, the immune system, and intestinal microorganisms. Hsp60 is a chaperonin component of the chaperoning system, present in all cells and tissues, including the intestine. It plays important roles in cell physiology outside and inside mitochondria, its canonical place of residence. However, Hsp60 can also be pathogenic in many conditions, the Hsp60 chaperonopathies, possibly including IBD. The various clinico-pathological types of IBD have a complicated mix of causative factors, among which Hsp60 can be considered a putatively important driver of events and could play an etiopathogenic role. This possibility is discussed in this review. We also indicate that Hsp60 can be a biomarker useful in disease diagnosing and monitoring and, if found active in pathogenesis, should become a target for developing new therapies. The latter are particularly needed to alleviate patient suffering and to prevent complications, including colon cancer. Copyright 2019 The Authors.
    Sponsors
    Part of this work was funded by the Italian National Operational Programme (PON) “Imprese e Competitività” 2014–2020 FESR, grant awarded by the Italian Ministry of Economic Development to the project titled “Gestione di un servizio integrato multicentrico di diagnostica e terapia personalizzata in oncologia” (Project code: F/090012/01-02/X36). AJLM and ECdeM were partially supported by IMET. FC was partially supported by IEMEST and UniPA.
    Keyword
    Chaperoning system
    Chaperonopathy
    Chaperonotherapy
    Hsp60
    Immune system
    Inflammatory bowel disease
    Intestinal wall
    Microbiota
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065907026&doi=10.3389%2ffphar.2019.00026&partnerID=40&md5=3e723126f3df1e259b9d841036ccb659; http://hdl.handle.net/10713/10658
    ae974a485f413a2113503eed53cd6c53
    10.3389/fphar.2019.00026
    Scopus Count
    Collections
    UMB Open Access Articles 2019

    entitlement

     
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.