Show simple item record

dc.contributor.authorApinjoh, T.O.
dc.contributor.authorOuattara, A.
dc.contributor.authorTitanji, V.P.K.
dc.date.accessioned2019-09-13T16:41:55Z
dc.date.available2019-09-13T16:41:55Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068895175&doi=10.1186%2fs12936-019-2844-5&partnerID=40&md5=a7ee667599293eaee534976b87d0abd0
dc.identifier.urihttp://hdl.handle.net/10713/10643
dc.description.abstractThe intensification of malaria control interventions has resulted in its global decline, but it remains a significant public health burden especially in sub-Saharan Africa (sSA). Knowledge on the parasite diversity, its transmission dynamics, mechanisms of adaptation to environmental and interventional pressures could help refine or develop new control and elimination strategies. Critical to this is the accurate assessment of the parasite's genetic diversity and monitoring of genetic markers of anti-malarial resistance across all susceptible populations. Such wide molecular surveillance will require selected tools and approaches from a variety of ever evolving advancements in technology and the changing epidemiology of malaria. The choice of an effective approach for specific endemic settings remains challenging, particularly for countries in sSA with limited access to advanced technologies. This article examines the current strategies and tools for Plasmodium falciparum genetic diversity typing and resistance monitoring and proposes how the different tools could be employed in resource-poor settings. Advanced approaches enabling targeted deep sequencing is valued as a sensitive method for assessing drug resistance and parasite diversity but remains out of the reach of most laboratories in sSA due to the high cost of development and maintenance. It is, however, feasible to equip a limited number of laboratories as Centres of Excellence in Africa (CEA), which will receive and process samples from a network of peripheral laboratories in the continent. Cheaper, sensitive and portable real-time PCR methods can be used in peripheral laboratories to pre-screen and select samples for targeted deep sequence or genome wide analyses at these CEAs.en_US
dc.description.urihttps://doi.org/10.1186/s12936-019-2844-5en_US
dc.language.isoen-USen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofMalaria journal
dc.subjectDrug resistanceen_US
dc.subjectGenetic diversityen_US
dc.subjectMonitoringen_US
dc.subjectPlasmodium falciparumen_US
dc.titleGenetic diversity and drug resistance surveillance of Plasmodium falciparum for malaria elimination: is there an ideal tool for resource-limited sub-Saharan Africa?en_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12936-019-2844-5
dc.identifier.pmid31242921


This item appears in the following Collection(s)

Show simple item record