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    Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study

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    Author
    Tang, S.
    Xu, S.
    Waddell, J.
    Date
    2019
    Journal
    Developmental Neuroscience
    Publisher
    S. Karger AG
    Type
    Article
    
    Metadata
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    See at
    https://doi.org/10.1159/000499183
    Abstract
    Prenatal ethanol exposure alters brain structure, functional connectivity, and behavior in humans and rats. Behavioral changes include deficits in executive function, which requires cooperative activity between the frontal cortices and other brain regions. In this study, we analyzed the functional connectivity and neurochemical levels of the prefrontal cortex (PFC) using resting-state functional magnetic resonance imaging (rsfMRI) and proton magnetic resonance spectroscopy ( 1 H-MRS) in ethanol-exposed (Eth) and control (Ctr) rats. Pregnant Long-Evans rats were fed a liquid diet containing ethanol (2.1-6.46% v/v ethanol) from gestational days 6 to 21 (Eth). Ctr animals received an isocaloric, isonutritive liquid diet. In young adulthood, male and female offspring underwent in vivo MRI using a 7.0-Tesla system. 1 H-MRS from the PFC and whole brain rsfMRI were obtained on the animals. Seed-based functional connectivity analysis was performed with seeds placed in the PFC, matching the voxel of MRS. Male, but not female, Eth rats showed less functional connectivity between PFC and dorsal striatum than Ctr animals. In Eth males glucose levels were significantly lower, and in Eth females lower levels of phosphorylcholine but an increased gamma-aminobutyric acid/glutamate ratio were observed in the PFC compared with Ctr animals. Prenatal ethanol alters brain metabolism and functional connectivity of the PFC in a sex-dependent manner. Copyright 2019 S. Karger AG, Basel.
    Keyword
    Blood oxygen level-dependent signal
    Cognition
    Fetal alcohol spectrum disorder
    Neurochemistry
    Sex differences
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064986315&doi=10.1159%2f000499183&partnerID=40&md5=0ecfbb336c4034dcf0c1151d7e1d7706; http://hdl.handle.net/10713/10638
    ae974a485f413a2113503eed53cd6c53
    10.1159/000499183
    Scopus Count
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    UMB Open Access Articles 2019

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