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dc.contributor.authorHarris, D.N.
dc.contributor.authorRuczinski, I.
dc.contributor.authorYanek, L.R.
dc.date.accessioned2019-09-13T14:49:34Z
dc.date.available2019-09-13T14:49:34Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85066163599&doi=10.1093%2fgbe%2fevz071&partnerID=40&md5=0f592b3ac10cdb670d9b470f1393e2db
dc.identifier.urihttp://hdl.handle.net/10713/10627
dc.description.abstractThe metabolic conversion of dietary omega-3 and omega-6 18 carbon (18C) to long chain (>20 carbon) polyunsaturated fatty acids (LC-PUFAs) is vital for human life. The rate-limiting steps of this process are catalyzed by fatty acid desaturase (FADS) 1 and 2. Therefore, understanding the evolutionary history of the FADS genes is essential to our understanding of hominin evolution. The FADS genes have two haplogroups, ancestral and derived, with the derived haplogroup being associated with more efficient LC-PUFA biosynthesis than the ancestral haplogroup. In addition, there is a complex global distribution of these haplogroups that is suggestive of Neanderthal introgression. We confirm that Native American ancestry is nearly fixed for the ancestral haplogroup, and replicate a positive selection signal in Native Americans. This positive selection potentially continued after the founding of the Americas, although simulations suggest that the timing is dependent on the allele frequency of the ancestral Beringian population. We also find that the Neanderthal FADS haplotype is more closely related to the derived haplogroup and the Denisovan clusters closer to the ancestral haplogroup. Furthermore, the derived haplogroup has a time to the most recent common ancestor of 688,474 years before present. These results support an ancient polymorphism, as opposed to Neanderthal introgression, forming in the FADS region during the Pleistocene with possibly differential selection pressures on both haplogroups. The near fixation of the ancestral haplogroup in Native American ancestry calls for future studies to explore the potential health risk of associated low LC-PUFA levels in these populations. Copyright The Author(s) 2019.en_US
dc.description.urihttps://doi.org/10.1093/gbe/evz071en_US
dc.language.isoen-USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofGenome Biology and Evolution
dc.subjectAncient DNAen_US
dc.subjectEvolutionen_US
dc.subjectPolyunsaturated fatty acidsen_US
dc.subjectPopulation geneticsen_US
dc.titleEvolution of hominin polyunsaturated fatty acid metabolism: From Africa to the New Worlden_US
dc.typeArticleen_US
dc.identifier.doi10.1093/gbe/evz071
dc.identifier.pmid30942856


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