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dc.contributor.authorSchumacher, M.
dc.contributor.authorNicholson, V.P.
dc.contributor.authorStoffel, M.H.
dc.date.accessioned2019-09-13T14:49:34Z
dc.date.available2019-09-13T14:49:34Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85069227927&doi=10.3389%2ffmicb.2019.01344&partnerID=40&md5=bdbd3cf9d271b834a4b580fc2f4986ed
dc.identifier.urihttp://hdl.handle.net/10713/10626
dc.description.abstractMembers of the "Mycoplasma mycoides cluster" are important animal pathogens causing diseases including contagious bovine pleuropneumonia and contagious caprine pleuropneumonia, which are of utmost importance in Africa or Asia. Even if all existing vaccines have shortcomings, vaccination of herds is still considered the best way to fight mycoplasma diseases, especially with the recent and dramatic increase of antimicrobial resistance observed in many mycoplasma species. A new generation of vaccines will benefit from a better understanding of the pathogenesis of mycoplasmas, which is very patchy up to now. In particular, surface-exposed virulence traits are likely to induce a protective immune response when formulated in a vaccine. The candidate virulence factor L-α-glycerophosphate oxidase oxidase (GlpO), shared by many mycoplasmas including Mycoplasma pneumoniae, was suggested to be a surface-exposed enzyme in Mycoplasma mycoides subsp. mycoides responsible for the production of hydrogen peroxide directly into the host cells. We produced a glpO isogenic mutant GM12en_US
dc.description.sponsorshipThis work was supported by the National Science Foundation (Grant No. IOS-1110151, http://www.nsf.gov) and by the International Development Research Centre (Grant No. 108625, https://www.idrc.ca).en_US
dc.description.urihttps://doi.org/10.3389/fmicb.2019.01344en_US
dc.language.isoen-USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Microbiology
dc.subject"Mycoplasma mycoides cluster"en_US
dc.subjectL-α-glycerophosphate oxidase oxidaseen_US
dc.subjectMycoplasma virulence traitsen_US
dc.subjectScanning electron microscopyen_US
dc.subjectSynthetic genomicsen_US
dc.subjectTriton X-114en_US
dc.titleEvidence for the cytoplasmic localization of the L-α-glycerophosphate oxidase in members of the "Mycoplasma mycoides Cluster"en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fmicb.2019.01344


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