Could Postnatal Age-Related Uridine Diphosphate Glucuronic Acid Be a Rate-Limiting Factor in the Metabolism of Morphine During the First Week of Life?
JournalCPT: Pharmacometrics and Systems Pharmacology
PublisherAmerican Society for Clinical Pharmacology and Therapeutics
MetadataShow full item record
AbstractNeonates experience dramatic changes in the disposition of drugs after birth as a result of enzyme maturation and environmental adjustment, challenging therapeutic decision making. In this research, we establish postnatal age, postmenstrual age, and body weight as physiologically reasonable predictors of morphine's clearance in neonates. By integrating knowledge of bilirubin, morphine, and other drugs metabolized by glucuronidation pathways from previously published studies, we hypothesize that uridine diphosphate glucuronic acid, a postnatal age-dependent sugar, plays an important role in the metabolism of morphine during the first week of life. This finding can be extended to other drugs metabolized by uridine diphosphate glucuronosyltransferase pathways in neonates and thus has important clinical implications for the use of drugs in this population. Copyright 2019 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.
SponsorsThe Diluted Tincture of Opium (DTO) study was funded by a Thomas Wilson grant and an institutional research grant from Johns Hopkins Hospital, General Clinical Research Center and was supported by National Institute on Drug Abuse Grant IR21DAO16288.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065734029&doi=10.1002%2fpsp4.12407&partnerID=40&md5=cf185d9a44a0f17a0c82f303bdaae9c6; http://hdl.handle.net/10713/10591