Date
2019Journal
Inflammatory bowel diseasesPublisher
Oxford AcademicType
Article
Metadata
Show full item recordAbstract
Pragmatic clinical research is part of five focus areas of the Challenges in IBD research document, which also includes preclinical human IBD mechanisms, environmental triggers, novel technologies, and precision medicine. The Challenges in IBD research document provides a comprehensive overview of current gaps in inflammatory bowel diseases (IBD) research and delivers actionable approaches to address them. It is the result of multidisciplinary input from scientists, clinicians, patients, and funders, and represents a valuable resource for patient centric research prioritization. In particular, the pragmatic clinical research section is focused on highlighting gaps that need to be addressed in order to optimize and standardize IBD care. Identified gaps include: 1) understanding the incidence and prevalence of IBD; 2) evaluating medication positioning to increase therapeutic effectiveness; 3) understanding the utility of therapeutic drug monitoring (TDM); 4) studying pain management; and 5) understanding healthcare economics and resources utilization. To address these gaps, there is a need to emphasize the use of emerging data sources and real-world evidence to better understand epidemiologic and therapeutic trends in IBD, expanding on existing data to better understand how and where we should improve care. Proposed approaches include epidemiological studies in ethnically and geographically diverse cohorts to estimate incidence and prevalence of IBD and impact of diversity on treatment patterns and outcomes. The implementation of new clinical trial design and methodologies will be essential to evaluate optimal medication positioning, appropriate use of TDM in adults and children, and multidisciplinary approaches to IBD pain management and its impact on healthcare resources. Copyright 2019 Crohn's & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.Keyword
claims dataclustered randomization
Crohn's disease
epidemiology
observational studies
pragmatic clinical research
randomized controlled trial
real-world evidence
registries
ulcerative colitis
Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066845279&doi=10.1093%2fibd%2fizz085&partnerID=40&md5=101fa8f22c5a1eda88117b359282c430; http://hdl.handle.net/10713/10572ae974a485f413a2113503eed53cd6c53
10.1093/ibd/izz085
Scopus Count
Collections
Related articles
- Challenges in IBD Research: Precision Medicine.
- Authors: Denson LA, Curran M, McGovern DPB, Koltun WA, Duerr RH, Kim SC, Sartor RB, Sylvester FA, Abraham C, de Zoeten EF, Siegel CA, Burns RM, Dobes AM, Shtraizent N, Honig G, Heller CA, Hurtado-Lorenzo A, Cho JH
- Issue date: 2019 May 16
- Challenges in IBD Research: Preclinical Human IBD Mechanisms.
- Authors: Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB
- Issue date: 2019 May 16
- Challenges in IBD Research: Environmental Triggers.
- Authors: Ho SM, Lewis JD, Mayer EA, Plevy SE, Chuang E, Rappaport SM, Croitoru K, Korzenik JR, Krischer J, Hyams JS, Judson R, Kellis M, Jerrett M, Miller GW, Grant ML, Shtraizent N, Honig G, Hurtado-Lorenzo A, Wu GD
- Issue date: 2019 May 16
- Challenges in IBD Research: Novel Technologies.
- Authors: Dhyani M, Joshi N, Bemelman WA, Gee MS, Yajnik V, D'Hoore A, Traverso G, Donowitz M, Mostoslavsky G, Lu TK, Lineberry N, Niessen HG, Peer D, Braun J, Delaney CP, Dubinsky MC, Guillory AN, Pereira M, Shtraizent N, Honig G, Polk DB, Hurtado-Lorenzo A, Karp JM, Michelassi F
- Issue date: 2019 May 16
- Approaches to improve quality of care in inflammatory bowel diseases.
- Authors: Shah R, Hou JK
- Issue date: 2014 Jul 28