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dc.contributor.authorPsotka, M.A.
dc.contributor.authorGottlieb, S.S.
dc.contributor.authorFrancis, G.S.
dc.date.accessioned2019-09-13T14:49:29Z
dc.date.available2019-09-13T14:49:29Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85064687087&doi=10.1016%2fj.jacc.2019.02.051&partnerID=40&md5=093c6e05e32b9dc22bbeb2224d549f66
dc.identifier.urihttp://hdl.handle.net/10713/10568
dc.description.abstractThe term “inotrope” is familiar and intimately connected with pharmaceuticals clinically used for treatment of low cardiac output with cardiogenic shock. Traditional inotropic agents exert their effect by modulating calcium signaling in the myocardium. Their use is associated with poor long-term outcomes. Newer molecules in development intend to break from calcium mediation and the associated detrimental long-term effects by targeting distinct mechanisms of action to improve cardiac performance. Thus, “inotropy” does not sufficiently describe the range of potential novel pharmaceutical products. To enhance communication around and evaluation of current, emerging, and potential therapies, this review proposes a novel nuanced and holistic framework to categorize pharmacological agents that improve myocardial performance based on 3 myocardial mechanisms: calcitropes, which alter intracellular calcium concentrations; myotropes, which affect the molecular motor and scaffolding; and mitotropes, which influence energetics. Novel chemical entities can easily be incorporated into this structure, distinguishing themselves based on their mechanisms and clinical outcomes. © 2019 The Authorsen_US
dc.description.urihttps://doi.org/10.1016/j.jacc.2019.02.051en_US
dc.language.isoen-USen_US
dc.publisherElsevier USAen_US
dc.relation.ispartofJournal of the American College of Cardiology
dc.subjectcardiac contractilityen_US
dc.subjectheart failureen_US
dc.subjectinotropeen_US
dc.subjectsystolic functionen_US
dc.titleCardiac Calcitropes, Myotropes, and Mitotropes: JACC Review Topic of the Weeken_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jacc.2019.02.051
dc.identifier.pmid31072579


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