Antimicrobial efficacy of clindamycin and triple antibiotic paste as root canal medicaments on tubular infection: An in vitro study
JournalAustralian Endodontic Journal
PublisherWiley-Blackwell Publishing Asia
MetadataShow full item record
AbstractThis study compared the antibacterial effect of 2% clindamycin and 2% and 100% concentration of triple antibiotic paste (TAP) on an Enterococcus faecalis biofilm. Dentinal tubules of 100 root specimens were infected and randomly assigned to five groups. A total of 1000 mg mL−1 of TAP, 20 mg mL−1 of TAP and clindamycin, calcium hydroxide or methylcellulose (control) were placed in the root canal for 1 week. After treatment, dentine shavings were collected from 200 and 400 μm dentine depth and the number of colony‐forming units (CFU) per mg was determined. Reduction in viable bacteria in first three groups was significantly better than calcium hydroxide and control groups. However, the antimicrobial effectiveness among these three groups was not significantly different from each other. There was no significant difference between data at 200 and 400 μm in all groups except the Ca(OH)2 group. The antibiofilm effect of clindamycin was comparable with TAP, so it may be used instead of TAP.
SponsorsThis study was financially supported by the Deputy of Research, school of dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85052635433&doi=10.1111%2faej.12288&partnerID=40&md5=d0734bada7df28c618f2d94cc9514c75; http://hdl.handle.net/10713/10555
- Antifungal effectiveness of various intracanal medicaments against Candida albicans: an ex-vivo study.
- Authors: Chua EG, Parolia A, Ahlawat P, Pau A, Amalraj FD
- Issue date: 2014 May 13
- Antibiofilm efficacy of photoactivated curcumin, triple and double antibiotic paste, 2% chlorhexidine and calcium hydroxide against Enterococcus fecalis in vitro.
- Authors: Devaraj S, Jagannathan N, Neelakantan P
- Issue date: 2016 Apr 21
- Effectiveness of antibiotic medicaments against biofilm formation of Enterococcus faecalis and Porphyromonas gingivalis.
- Authors: Sabrah AH, Yassen GH, Gregory RL
- Issue date: 2013 Nov
- Antibiofilm efficacy of silver nanoparticles as a vehicle for calcium hydroxide medicament against Enterococcus faecalis.
- Authors: Afkhami F, Pourhashemi SJ, Sadegh M, Salehi Y, Fard MJ
- Issue date: 2015 Dec
- Intratubular disinfection with tri-antibiotic and calcium hydroxide pastes.
- Authors: Pereira TC, Vasconcelos LR, Graeff MS, Duarte MA, Bramante CM, Andrade FB
- Issue date: 2017 Mar