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dc.contributor.authorLamprea-Montealegre, J.A.
dc.contributor.authorChristenson, R.
dc.contributor.authorSeliger, S.L.
dc.date.accessioned2019-09-10T17:30:16Z
dc.date.available2019-09-10T17:30:16Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071171058&doi=10.1161%2fJAHA.119.012200&partnerID=40&md5=479bdfe3d48e75c2c2040bcce464d7fe
dc.identifier.urihttp://hdl.handle.net/10713/10495
dc.description.abstractBackground: We tested associations of cardiac biomarkers of myocardial stretch, injury, inflammation, and fibrosis with the risk of incident atrial fibrillation (AF) in a prospective study of chronic kidney disease patients. Methods and Results: The study sample was 3053 participants with chronic kidney disease in the multicenter CRIC (Chronic Renal Insufficiency Cohort) study who were not identified as having AF at baseline. Cardiac biomarkers, measured at baseline, were NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), high‐sensitivity troponin T, galectin‐3, growth differentiation factor‐15, and soluble ST‐2. Incident AF (“AF event”) was defined as a hospitalization for AF. During a median follow‐up of 8 years, 279 (9%) participants developed a new AF event. In adjusted models, higher baseline log‐transformed NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) was associated with incident AF (adjusted hazard ratio [HR] per SD higher concentration: 2.11; 95% CI, 1.75, 2.55), as was log‐high‐sensitivity troponin T (HR 1.42; 95% CI, 1.20, 1.68). These associations showed a dose–response relationship in categorical analyses. Although log‐soluble ST‐2 was associated with AF risk in continuous models (HR per SD higher concentration 1.35; 95% CI, 1.16, 1.58), this association was not consistent in categorical analyses. Log‐galectin‐3 (HR 1.05; 95% CI, 0.91, 1.22) and log‐growth differentiation factor‐15 (HR 1.16; 95% CI, 0.96, 1.40) were not significantly associated with incident AF. Conclusions: We found strong associations between higher NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) and high‐sensitivity troponin T concentrations, and the risk of incident AF in a large cohort of participants with chronic kidney disease. Increased atrial myocardial stretch and myocardial cell injury may be implicated in the high burden of AF in patients with chronic kidney disease.en_US
dc.description.urihttps://doi.org/10.1161/JAHA.119.012200en_US
dc.language.isoen-USen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.ispartofJournal of the American Heart Association
dc.subjectatrial fibrillationen_US
dc.subjectbiomarkeren_US
dc.subjectchronic kidney diseaseen_US
dc.titleCardiac Biomarkers and Risk of Atrial Fibrillation in Chronic Kidney Disease: The CRIC Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/JAHA.119.012200
dc.identifier.pmid31379242


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