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dc.contributor.authorLee, M.H.
dc.contributor.authorLapidus, R.G.
dc.contributor.authorEmadi, A.
dc.date.accessioned2019-09-10T17:30:15Z
dc.date.available2019-09-10T17:30:15Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071401667&doi=10.3390%2fmolecules24173121&partnerID=40&md5=4b1e7cc3c8d7dfe7fc98aa686bd2bbb4
dc.identifier.urihttp://hdl.handle.net/10713/10489
dc.description.abstractAcute myeloid leukemia (AML) is a neoplastic disorder resulting from clonal proliferation of poorly differentiated immature myeloid cells. Distinct genetic and epigenetic aberrations are key features of AML that account for its variable response to standard therapy. Irrespective of their oncogenic mutations, AML cells produce elevated levels of reactive oxygen species (ROS). They also alter expression and activity of antioxidant enzymes to promote cell proliferation and survival. Subsequently, selective targeting of redox homeostasis in a molecularly heterogeneous disease, such as AML, has been an appealing approach in the development of novel anti-leukemic chemotherapeutics. Naphthoquinones are able to undergo redox cycling and generate ROS in cancer cells, which have made them excellent candidates for testing against AML cells. In addition to inducing oxidative imbalance in AML cells, depending on their structure, naphthoquinones negatively affect other cellular apparatus causing neoplastic cell death. Here we provide an overview of the anti-AML activities of naphthoquinone derivatives, as well as analysis of their mechanism of action, including induction of reduction-oxidation imbalance, alteration in mitochondrial transmembrane potential, Bcl-2 modulation, initiation of DNA damage, and modulation of MAPK and STAT3 activity, alterations in the unfolded protein response and translocation of FOX-related transcription factors to the nucleus. Copyright 2019 by the authors.en_US
dc.description.urihttps://doi.org/10.3390/molecules24173121en_US
dc.language.isoen-USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofMolecules
dc.subjectAcute myeloid leukemia (AML)en_US
dc.subjectApoptosisen_US
dc.subjectMechanism of actionen_US
dc.subjectNaphthoquinoneen_US
dc.subjectReactive oxygen species (ROS)en_US
dc.titleAnalysis of the mechanisms of action of naphthoquinone-based anti-acute myeloid leukemia chemotherapeuticsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/molecules24173121
dc.identifier.pmid31466259


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