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dc.contributor.authorJung, H.J.
dc.contributor.authorKwon, T.-H.
dc.date.accessioned2019-08-26T14:44:30Z
dc.date.available2019-08-26T14:44:30Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85070635510&doi=10.23876%2fj.krcp.19.002&partnerID=40&md5=8e2e5d82b64dd534dd67209905f1b8fd
dc.identifier.urihttp://hdl.handle.net/10713/10422
dc.description.abstractThe kidney collecting duct (CD) is a tubular segment of the kidney where the osmolality and final flow rate of urine are established, enabling urine concentration and body water homeostasis. Water reabsorption in the CD depends on the action of arginine vasopressin (AVP) and a transepithelial osmotic gradient between the luminal fluid and surrounding interstitium. AVP induces transcellular water reabsorption across CD principal cells through associated signaling pathways after binding to arginine vasopressin receptor 2 (AVPR2). This signaling cascade regulates the water channel protein aquaporin-2 (AQP2). AQP2 is exclusively localized in kidney connecting tubules and CDs. Specifically, AVP stimulates the intracellular translocation of AQP2-containing vesicles to the apical plasma membrane, increasing the osmotic water permeability of CD cells. Moreover, AVP induces transcription of the Aqp2 gene, increasing AQP2 protein abundance. This review provides new insights into the transcriptional regulation of the Aqp2 gene in the kidney CD with an overview of AVP and AQP2. It summarizes current therapeutic approaches for X-linked nephrogenic diabetes insipidus caused by AVPR2 gene mutations.en_US
dc.description.sponsorshipThis research was supported by Kyungpook National University Research Fund, 2018.en_US
dc.description.urihttps://doi.org/10.23876/j.krcp.19.002en_US
dc.language.isoen-USen_US
dc.publisherThe Korean Society of Nephrologyen_US
dc.relation.ispartofKidney Research and Clinical Practice
dc.subjectAquaporin-2en_US
dc.subjectArginine vasopressinen_US
dc.subjectG-protein coupled receptorsen_US
dc.subjectGene expression regulationen_US
dc.subjectNephrogenic diabetes insipidusen_US
dc.titleNew insights into the transcriptional regulation of aquaporin-2 and the treatment of X-linked hereditary nephrogenic diabetes insipidusen_US
dc.typeArticleen_US
dc.identifier.doi10.23876/j.krcp.19.002


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