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    Liquid biopsy in lung cancer screening: The contribution of metabolomics. results of a pilot study

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    Author
    Singhal, S.
    Rolfo, C.
    Russo, A.
    Date
    2019
    Journal
    Cancers
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/cancers11081069
    Abstract
    Background: Lung cancer is the most common cause of cancer-related deaths worldwide. Early diagnosis is crucial to increase the curability chance of the patients. Low dose CT screening can reduce lung cancer mortality, but it is associated with several limitations. Metabolomics is a promising technique for cancer diagnosis due to its ability to provide chemical phenotyping data. The intent of our study was to explore metabolomic effects and profiles of lung cancer patients to determine if metabolic perturbations in the SSAT-1/polyamine pathway can distinguish between healthy participants and lung cancer patients as a diagnostic and treatment monitoring tool. Patients and Methods: Plasma samples were collected as part of the SSAT1 Amantadine Cancer Study. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to identify and quantify metabolite concentrations in lung cancer patient and control samples. Standard statistical analyses were performed to determine whether metabolite concentrations could differentiate between healthy subjects and lung cancer patients, as well as risk prediction modeling applied to determine whether metabolic profiles could provide an indication of cancer progression in later stage patients. Results: A panel consisting of 14 metabolites, which included 6 metabolites in the polyamine pathway, was identified that correctly discriminated lung cancer patients from controls with an area under the curve of 0.97 (95% CI: 0.875-1.0). Conclusion: When used in conjunction with the SSAT-1/polyamine pathway, these metabolites may provide the specificity required for diagnosing lung cancer from other cancer types and could be used as a diagnostic and treatment monitoring tool. Copyright 2019 by the authors.
    Sponsors
    The study was approved by the Institutional Review Board of the Ministry of Health & Family Welfare, the People's Republic of Bangladesh (No. 115-15882). Clinical studies were completed under GCP and GLP conditions in accordance with local standards as well as the standards established by the Canadian Tri-Council Policies.
    Keyword
    Lung cancer
    Metabolomic fingerprint
    Metabolomics
    NSCLC
    Polyamine
    SSAT-1
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070609489&doi=10.3390%2fcancers11081069&partnerID=40&md5=5f2b2ac450f79d42d5fb7fa8fe4fbfe4; http://hdl.handle.net/10713/10417
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers11081069
    Scopus Count
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    UMB Open Access Articles 2019

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