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dc.contributor.authorSakai-Kawada, F.E.
dc.contributor.authorIp, C.G.
dc.contributor.authorHagiwara, K.A.
dc.date.accessioned2019-08-26T14:44:27Z
dc.date.available2019-08-26T14:44:27Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85070794428&doi=10.3389%2ffmicb.2019.01715&partnerID=40&md5=af0e7865c045994ec7f0b543e32d0ed0
dc.identifier.urihttp://hdl.handle.net/10713/10395
dc.description.abstractThe Prodiginine family consists of primarily red-pigmented tripyrrole secondary metabolites that were first characterized in the Gram-negative bacterial species Serratia marcescens and demonstrates a wide array of biological activities and applications. Derivatives of prodiginine have since been characterized in the marine g-proteobacterium, Pseudoalteromonas. Although biosynthetic gene clusters involved in prodiginine synthesis display homology among genera, there is an evident structural difference in the resulting metabolites. This review will summarize prodiginine biosynthesis, bioactivity, and gene regulation in Pseudoalteromonas in comparison to the previously characterized species of Serratia, discuss the ecological contributions of Pseudoalteromonas in the marine microbiome and their eukaryotic hosts, and consider the importance of modern functional genomics and classic DNA manipulation to understand the overall prodiginine biosynthesis pathway. Copyright 2019 Sakai-Kawada, Ip, Hagiwara and Awaya.en_US
dc.description.sponsorshipThis research was supported by the United States National Science Foundation grant HRD 0833211.en_US
dc.description.urihttps://doi.org/10.3389/fmicb.2019.01715en_US
dc.language.isoen-USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Microbiology
dc.subjectMarine bacteriaen_US
dc.subjectPigmentsen_US
dc.subjectProdigininesen_US
dc.subjectProdigiosinen_US
dc.subjectPseudoalteromonasen_US
dc.subjectSecondary metabolitesen_US
dc.titleBiosynthesis and bioactivity of prodiginine analogs in marine bacteria, Pseudoalteromonas: A mini reviewen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fmicb.2019.01715


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