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    A Novel Dental Sealant Containing Dimethylaminohexadecyl Methacrylate Suppresses the Cariogenic Pathogenicity of Streptococcus mutans Biofilms

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    Author
    Ibrahim, M.S.
    Balhaddad, A.A.
    Weir, M.D.
    Oates, T.W.
    Xu, H.H.K.
    Melo, M.A.S.
    Date
    2019
    Journal
    International journal of molecular sciences
    Publisher
    MDPI
    Type
    Article
    
    Metadata
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    See at
    https://www.doi.org/10.3390/ijms20143491
    Abstract
    Cariogenic oral biofilms are strongly linked to dental caries around dental sealants. Quaternary ammonium monomers copolymerized with dental resin systems have been increasingly explored for modulation of biofilm growth. Here, we investigated the effect of dimethylaminohexadecyl methacrylate (DMAHDM) on the cariogenic pathogenicity of Streptococcus mutans (S. mutans) biofilms. DMAHDM at 5 mass% was incorporated into a parental formulation containing 20 mass% nanoparticles of amorphous calcium phosphate (NACP). S. mutans biofilms were grown on the formulations, and biofilm inhibition and virulence properties were assessed. The tolerances to acid stress and hydrogen peroxide stress were also evaluated. Our findings suggest that incorporating 5% DMAHDM into 20% NACP-containing sealants (1) imparts a detrimental biological effect on S. mutans by reducing colony-forming unit counts, metabolic activity and exopolysaccharide synthesis; and (2) reduces overall acid production and tolerance to oxygen stress, two major virulence factors of this microorganism. These results provide a perspective on the value of integrating bioactive restorative materials with traditional caries management approaches in clinical practice. Contact-killing strategies via dental materials aiming to prevent or at least reduce high numbers of cariogenic bacteria may be a promising approach to decrease caries in patients at high risk.
    Keyword
    antibacterial agents
    biofilm
    dental caries
    quaternary ammonium compounds
    sealant
    Streptococcus mutans
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070074318&doi=10.3390%2fijms20143491&partnerID=40&md5=b2d83d3c1392088abd3af53b2b265e3c; http://hdl.handle.net/10713/10370
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms20143491
    Scopus Count
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    UMB Open Access Articles 2019

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