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dc.contributor.authorFinch, C.L.
dc.contributor.authorPasetti, M.F.
dc.contributor.authorXie, H.
dc.date.accessioned2019-08-16T13:45:22Z
dc.date.available2019-08-16T13:45:22Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85070068799&doi=10.1080%2f22221751.2019.1648184&partnerID=40&md5=d0f52f74121aa78e36b6338cb671d076
dc.identifier.urihttp://hdl.handle.net/10713/10349
dc.description.abstractEstradiol, a major female steroid produced during pregnancy, has been reported to protect ovariectomized animals against H1N1 influenza infections via its anti-inflammatory effects. However, it remains unclear why pregnant women with high gestational estradiol levels are highly susceptible to influenza infections. This study was aimed to investigate the effects of pregnancy level of estradiol on female immunity against H5N1 infection in Balb/c mice. A sex-dependent susceptibility to H5N1 infection (higher morbidity and higher mortality) was observed in both pregnant and non-pregnant female mice as compared to male mice. Subcutaneous implantation of estradiol pellets increased serum estradiol concentrations of non-pregnant female mice to the pregnancy level. These mice were protected from H5N1 infection through downregulation of pulmonary pro-inflammatory cytokines. However, the production of virus-specific antibodies after infection was significantly delayed in estradiol-implanted mice when compared to placebos. Virus-specific IgG-secreting and IL-4-secreting cells were also reduced in estradiol-implanted mice. Similarly, lower antibody titers to seasonal vaccine antigens were found in pregnant women as compared to non-pregnant females without hormone usage. Our results indicate that estradiol levels equivalent to those found during pregnancy have divergent effects on female immunity against influenza, highlighting the importance of vaccination during pregnancy to prevent severe influenza infections. Copyright 2019 The Author(s).en_US
dc.description.sponsorshipThis work was supported by the FDA Office of Women's Health (OWH) fund (to Xie H). CL Finch and A. Zhang were on the FDA OWH sponsored ORISE Research Fellowship via the administration of the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and FDA/CBER.en_US
dc.description.urihttps://www.doi.org/10.1080/22221751.2019.1648184en_US
dc.language.isoen-USen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofEmerging Microbes and Infections
dc.subjectavian influenzaen_US
dc.subjecthumoral immunityen_US
dc.subjectPregnancy level of estradiolen_US
dc.subjectsex-biaseden_US
dc.subjectTh2 responseen_US
dc.titlePregnancy level of estradiol attenuated virus-specific humoral immune response in H5N1-infected female mice despite inducing anti-inflammatory protectionen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/22221751.2019.1648184


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