Stereolithography (STL) Code File: Digital Design and Fabrication of a Universal Rat Intraoral Device
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DescriptionCode file generated from the 3Shape Dental Design software for printing the device. STL format is supported by any software packages used for computer-aided design (CAD), 3D printing, rapid prototyping, and computer-aided manufacturing (CAM).
Denture stomatitis is a persistent and chronic oral infection of the denture-bearing palatal mucosa that is prevalent in denture wearers. However, there are currently no feasible therapeutic strategies for the prevention of this recurrent condition. In order to study this disease and evaluate novel therapeutic strategies, a suitable animal model mimicking the infectious process in humans is warranted. To that end, using the latest technological advances in dental digital design and 3D printing, we fabricated an intraoral device for rats with universal fit. The device was successfully installed and used to develop clinical DS.
To design the rat intraoral device, an impression of the rat palate was made. Impressions were used to create a mold that was then scanned and used to digitally design one universal device. Using 3Shape Dental Design software, a reservoir was incorporated in the design to provide space between device and palate for the therapeutic formulation. The device was then modified in Meshmixer to also incorporate a surface perforation that accommodates the diameter of a 200 µL pipette tip, through which microbial cell suspension or therapeutic formulations can be rapidly administered into the reservoir area. In addition, slits were created on both sides of the device to fit above the molars of the rats through which flowable composite can be introduced for cementing the denture to the teeth. The device was then 3D printed in class 1 biocompatible SG-resin (FDA 510K Exempt) and installed on rat palates.