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dc.contributor.authorTibbs, Maria
dc.date.accessioned2019-08-05T17:33:04Z
dc.date.available2019-08-05T17:33:04Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/10713/10258
dc.description2019
dc.descriptionBiomedical Sciences-Dental School
dc.descriptionUniversity of Maryland, Baltimore
dc.descriptionM.S.
dc.description.abstractCreating a stronger transmucosal seal around the implant abutment may help prevent epithelial downgrowth and resultant crestal bone loss. Most studies focus on titanium and zirconium, but provisional restorations are gaining popularity and these materials require further study. Previous in vitro models utilize a monoculture technique to understand cell behavior, which makes direct intercellular comparisons difficult. Our first aim was to develop a co-culture of human gingival fibroblasts and human oral keratinocytes. Then, cell attachment, proliferation, and migration across six commercially available abutment materials was ascertained and comparisons drawn. Discs made of smooth titanium, (control), rough titanium, CAD/CAM poly (methylmethacrylate), poly ether etherketone, smooth zirconium, and rough zirconium were chosen. Preliminary results indicate that at various time points, significant differences in fibroblast and keratinocyte proliferation and attachment exist among abutment materials.
dc.subject.meshCoculture Techniquesen_US
dc.subject.meshDental Abutmentsen_US
dc.subject.meshDental Implantsen_US
dc.subject.meshFibroblastsen_US
dc.subject.meshKeratinocytesen_US
dc.titleAbutment Material Affects the Attachment of Co-cultured Fibroblasts and Keratinocytes
dc.typedissertationen_US
dc.date.updated2019-08-02T19:00:44Z
dc.language.rfc3066en
dc.contributor.advisorSaito, Hanae
refterms.dateFOA2019-08-05T17:33:04Z


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