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    Protein-based vehicles for biomimetic RNAi delivery

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    Author
    Pottash, A.E.
    Kuffner, C.
    Noonan-Shueh, M.
    Date
    2019
    Journal
    Journal of Biological Engineering
    Publisher
    BioMed Central Ltd.
    Type
    article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s13036-018-0130-7
    Abstract
    Broad translational success of RNA interference (RNAi) technology depends on the development of effective delivery approaches. To that end, researchers have developed a variety of strategies, including chemical modification of RNA, viral and non-viral transfection approaches, and incorporation with delivery vehicles such as polymer- and lipid-based nanoparticles, engineered and native proteins, extracellular vesicles (EVs), and others. Among these, EVs and protein-based vehicles stand out as biomimetically-inspired approaches, as both proteins (e.g. Apolipoprotein A-1, Argonaute 2, and Arc) and EVs mediate intercellular RNA transfer physiologically. Proteins specifically offer significant therapeutic potential due to their biophysical and biochemical properties as well as their ability to facilitate and tolerate manipulation; these characteristics have made proteins highly successful translational therapeutic molecules in the last two decades. This review covers engineered protein vehicles for RNAi delivery along with what is currently known about naturally-occurring extracellular RNA carriers towards uncovering design rules that will inform future engineering of protein-based vehicles. Copyright 2019 The Author(s).
    Sponsors
    The authors acknowledge support from the National Institutes of Health (HL141611), the National Science Foundation (1750542)
    Keyword
    Arc
    Argonaute
    Drug delivery
    Lipoprotein
    Protein engineering
    RNAi
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062461448&doi=10.1186%2fs13036-018-0130-7&partnerID=40&md5=d4ba6b5fe8c9096f1e5914c6cb76db81; http://hdl.handle.net/10713/10254
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13036-018-0130-7
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