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    Agglutination testing for human erythrocyte product in the rhesus macaque

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    Author
    Jackson, I.L.
    Vicente, E.
    Yazer, M.H.
    Date
    2019
    Journal
    Transfusion
    Publisher
    Blackwell Publishing Inc.
    Type
    article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1111/trf.15182
    Abstract
    INTRODUCTION: There has been interest in using human blood products in nonhuman primate models of trauma to supplement human studies and to provide evidence to guide novel trauma resuscitation strategies. The compatibility of human RBCs has not been extensively studied in nonhuman primate species. METHODS: Whole blood samples were collected from five healthy, nontransfused, not previously pregnant Chinese-bred rhesus macaques. The whole blood was centrifuged, and the plasma was decanted from each sample. Group O-negative human RBCs were mixed with the plasma from the rhesus macaque monkeys. Compatibility testing was performed by an immediate spin test and polyspecific and monospecific anti-human globulin (AHG) tests in glass tubes. RESULTS: Immediate spin testing revealed three out of five plasma samples (60%) from rhesus macaques caused at least 1+ agglutination with the human RBCs. Polyspecific anti-human globulin (AHG) tests demonstrated that two of five plasma samples (40%) from rhesus macaques caused at least 1+ agglutination with the human RBC, while the monospecific AHG testing revealed that the incompatibility was caused by C3d, not IgG. CONCLUSION: Human RBCs are not compatible with the plasma of some, but not all, Chinese-bred rhesus macaques.
    Sponsors
    This study was financially supported by the Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21231.
    Keyword
    human
    compatibility
    Erythrocytes
    Agglutination Tests
    Macaca mulatta
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061243541&doi=10.1111%2ftrf.15182&partnerID=40&md5=8479d75ac20f1b85a4caa796d365ed66; http://hdl.handle.net/10713/10246
    ae974a485f413a2113503eed53cd6c53
    10.1111/trf.15182
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