Show simple item record

dc.contributor.authorDeitchman, A.R.
dc.contributor.authorKalchiem-Dekel, O.
dc.contributor.authorTodd, N.
dc.date.accessioned2019-08-05T17:00:32Z
dc.date.available2019-08-05T17:00:32Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85067336634&doi=10.1016%2fj.rmcr.2019.100886&partnerID=40&md5=e57b5dc6babcf1fb5120c4fff93606e6
dc.identifier.urihttp://hdl.handle.net/10713/10239
dc.description.abstractThe association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein, we describe a previously well 51-year-old man who presented with three months of progressive small joint arthritis, cough, dyspnea, and eventually hypoxemic respiratory failure following a viral prodrome. He continued to decompensate despite high dose corticosteroids and mycophenolate mofetil, ultimately requiring extracorporeal membranous oxygenation as a bridge to bilateral lung transplantation. Clinically amyopathic dermatomyositis (CADM) was confirmed through serum positivity for anti-Melanoma Differentiation Associated Protein-5 (MDA-5) antibody. Interestingly, his post-operative course was complicated by a zoonotic infection with Bordetella bronchiseptica. This case highlights the importance of identifying rare autoimmune diseases, and the utility of transfer to a lung transplant center. Copyright 2019 The Authorsen_US
dc.description.urihttps://doi.org/10.1016/j.rmcr.2019.100886en_US
dc.language.isoen-USen_US
dc.publisherW.B. Saunders Ltden_US
dc.relation.ispartofRespiratory Medicine Case Reports
dc.subjectanti-melanoma differentiation associated protein-5en_US
dc.subject.meshLung Diseases, Interstitialen_US
dc.subject.meshLung Transplantationen_US
dc.titleRapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel coughen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.rmcr.2019.100886


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record