Show simple item record

dc.contributor.authorScanlon, K.
dc.contributor.authorSkerry, C.
dc.contributor.authorCarbonetti, N.
dc.date.accessioned2019-08-05T17:00:32Z
dc.date.available2019-08-05T17:00:32Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068726610&doi=10.3390%2ftoxins11070373&partnerID=40&md5=84c94709b84b1f744460f5b7b04a602f
dc.identifier.urihttp://hdl.handle.net/10713/10230
dc.description.abstractPertussis, caused by respiratory tract infection with the bacterial pathogen Bordetella pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and multiply extracellularly in the airways and release several toxins, which have a variety of effects on the host, both local and systemic. Predominant among these toxins is pertussis toxin (PT), a multi-subunit protein toxin that inhibits signaling through a subset of G protein-coupled receptors in mammalian cells. PT activity has been linked with severe and lethal pertussis disease in young infants and a detoxified version of PT is a common component of all licensed acellular pertussis vaccines. The role of PT in typical pertussis disease in other individuals is less clear, but significant evidence supporting its contribution to pathogenesis has been accumulated from animal model studies. In this review we discuss the evidence indicating a role for PT in pertussis disease, focusing on its contribution to severe pertussis in infants, modulation of immune and inflammatory responses to infection, and the characteristic paroxysmal cough of pertussis. Copyright 2019 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipThis research was funded by National Institutes of Health, grant numbers AI101055, AI119566, AI117095, AI135465, AI137778, AI141372 (to NC) and AI140035 (to CS).en_US
dc.description.urihttps://doi.org/10.3390/toxins11070373en_US
dc.language.isoen-USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofToxins
dc.subjectBacterial infectionen_US
dc.subjectCoughen_US
dc.subjectImmunomodulationen_US
dc.subjectInflammationen_US
dc.subjectLeukocytosisen_US
dc.subjectPertussis toxinen_US
dc.subjectPulmonary hypertensionen_US
dc.subjectRespiratory diseaseen_US
dc.titleAssociation of pertussis toxin with severe pertussis diseaseen_US
dc.typearticleen_US
dc.identifier.doi10.3390/toxins11070373
dc.identifier.pmid31252532


This item appears in the following Collection(s)

Show simple item record