Circulating and circular RNAs and the need for rationalization and synthesis of the research spiral
Date
2019Journal
Advances in clinical and experimental medicine : official organ Wroclaw Medical UniversityPublisher
Wroclaw Medical University PressType
article
Metadata
Show full item recordAbstract
In this essay, we aim to draw a short comparison between 2 important research topics - circular and circulating RNAs - and show how they are connected. The findings described here in the field of circular RNAs, which are still quite obscured by the rapidly expanding body of knowledge in biology, have added another dimension to our view of the process of gene expression, which is formed by a more complex network of molecule interactions than we previously thought. The term "circulating RNAs" refers to a broad spectrum of RNA fragments originating from different sources, such as physiologically dying cells, sites of inflammation or cancer cells, and fragments floating in human liquid tissues together with other elements. Fragments of nucleic acids circulating in blood are emerging as promising biomarkers in different medical conditions. Interestingly, circular RNAs have been found to be present in human blood and form a fraction of circulating RNAs. In addition to updating readers on these fast-developing areas of biology, we also stress the need for the study of complex networks of molecule interactions as whole structures (in unison with the thoughts of systems biology), as opposed to the trend toward searching for individual key player molecules. Fundamentally, we want to add to the rationalization and synthesis of new research findings in the scientific literature, because this direction is important not only for students, teachers and researchers, but also for the general population.Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069229312&doi=10.17219%2facem%2f94148&partnerID=40&md5=cc5baef50ad52f0e00a557818a4f0fbe; http://hdl.handle.net/10713/10219ae974a485f413a2113503eed53cd6c53
10.17219/acem/94148
Scopus Count
Collections
Related articles
- Circular RNAs in heart failure.
- Authors: Devaux Y, Creemers EE, Boon RA, Werfel S, Thum T, Engelhardt S, Dimmeler S, Squire I, Cardiolinc network
- Issue date: 2017 Jun
- Circular RNA: new star, new hope in cancer.
- Authors: Zhang Z, Xie Q, He D, Ling Y, Li Y, Li J, Zhang H
- Issue date: 2018 Aug 20
- Circular RNAs as a new field in gene regulation and their implications in translational research.
- Authors: Vidal AF, Sandoval GT, Magalhães L, Santos SE, Ribeiro-dos-Santos Â
- Issue date: 2016 Apr
- Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis.
- Authors: Iparraguirre L, Muñoz-Culla M, Prada-Luengo I, Castillo-Triviño T, Olascoaga J, Otaegui D
- Issue date: 2017 Sep 15
- The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases.
- Authors: E S, Costa MC, Kurc S, Drożdż A, Cortez-Dias N, Enguita FJ
- Issue date: 2018 Jul