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    Circulating and circular RNAs and the need for rationalization and synthesis of the research spiral

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    Author
    Dvorak, P.
    Leupen, S.
    Soucek, P.
    Date
    2019
    Journal
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University
    Publisher
    Wroclaw Medical University Press
    Type
    article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.17219/acem/94148
    Abstract
    In this essay, we aim to draw a short comparison between 2 important research topics - circular and circulating RNAs - and show how they are connected. The findings described here in the field of circular RNAs, which are still quite obscured by the rapidly expanding body of knowledge in biology, have added another dimension to our view of the process of gene expression, which is formed by a more complex network of molecule interactions than we previously thought. The term "circulating RNAs" refers to a broad spectrum of RNA fragments originating from different sources, such as physiologically dying cells, sites of inflammation or cancer cells, and fragments floating in human liquid tissues together with other elements. Fragments of nucleic acids circulating in blood are emerging as promising biomarkers in different medical conditions. Interestingly, circular RNAs have been found to be present in human blood and form a fraction of circulating RNAs. In addition to updating readers on these fast-developing areas of biology, we also stress the need for the study of complex networks of molecule interactions as whole structures (in unison with the thoughts of systems biology), as opposed to the trend toward searching for individual key player molecules. Fundamentally, we want to add to the rationalization and synthesis of new research findings in the scientific literature, because this direction is important not only for students, teachers and researchers, but also for the general population.
    Keyword
    circular RNA
    circulating RNA
    complex networks
    synthesis
    systems biology
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069229312&doi=10.17219%2facem%2f94148&partnerID=40&md5=cc5baef50ad52f0e00a557818a4f0fbe; http://hdl.handle.net/10713/10219
    ae974a485f413a2113503eed53cd6c53
    10.17219/acem/94148
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