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    Stability of individual differences in sucralose taste preference

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    Author
    Bacharach, S.Z.
    Calu, D.J.
    Date
    2019
    Journal
    PLoS ONE
    Publisher
    Public Library of Science
    Type
    article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1371/journal.pone.0216431
    Abstract
    Outbred rats display variable preferences for bittersweet solutions, expressed as preference or avoidance of high concentrations of artificial sweeteners over water. This may reflect individual differences in appetitive/aversive conflict processing that may have predictive validity for disorders of motivation. Here we use a homecage two-bottle choice procedure to examine the test/retest stability and between-tastant consistency in sucralose preference to determine the reliability of bittersweet taste preference. Sucralose is a non-caloric artificial sweetener that is preferred by some rats and avoided by others. We sought to determine whether sucralose preference is consistent with preference of sucrose/quinine solutions that have known sweet and bitter taste qualities, respectively. We give fluid restricted rats 45-minutes homecage access to water and ascending concentrations of sucralose (SUCRA; 0.0025-10mM) or a compound solution of sucrose (116mM) + quinine (0.002-2mM) (SQ). We use a within-subject counterbalanced design (SUCRA or SQ testing) to determine preference of each bittersweet solution relative to water. We observed individual variability in preference for SUCRA and SQ, such that some rats preferred bittersweet solutions over water (preferring) while other rats preferred water over bittersweet solutions (avoiding). Within tastant, this preference remained stable across repeated testing. Between solutions, SUCRA preference scores correlated with SQ scores, suggesting consistent taste conflict processing for both bittersweet solutions. Population level analyses confirmed that preference generalizes across bittersweet solutions, and that rats' preferences for bittersweet solutions relative to water are stable over time. The test/retest and between-tastant reliability of this taste conflict screening procedure support the potential utility of this model for exploring individual variability in appetitive/aversive conflict processes mediating motivated behavior. Copyright 2019 Bacharach, Calu.
    Keyword
    sucralose
    Food Preferences
    Rats
    Taste
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065773725&doi=10.1371%2fjournal.pone.0216431&partnerID=40&md5=b980e9ba37db1181a74baa79f2fb8c58; http://hdl.handle.net/10713/10187
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0216431
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