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    Evolution of our understanding of cell volume regulation by the pump-leak mechanism

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    Author
    Kay, A.R.
    Blaustein, M.P.
    Date
    2019
    Journal
    Journal of General Physiology
    Publisher
    Rockefeller University Press
    Type
    article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1085/jgp.201812274
    Abstract
    All animal cells are surrounded by a flexible plasma membrane that is permeable to water and to small ions. Cells thus face a fundamental problem: the considerable tension that their membranes would experience if the osmotic influx of water, driven by the presence of impermeant intracellular ions, was left unopposed. The pivotal study that described the cell's remedy for this impending osmotic catastrophe-the "pump-leak mechanism" (PLM)-was published in the Journal of General Physiology by Tosteson and Hoffman in 1960. Their work revealed how the sodium pump stabilizes cell volume by eliminating the osmotic gradient. Here we describe the mechanistic basis of the PLM, trace the history of its discovery, and place it into the context of our current understanding.
    Keyword
    pump leak mechanism
    Cell Physiological Phenomena
    Osmotic Pressure--physiology
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064193048&doi=10.1085%2fjgp.201812274&partnerID=40&md5=a4dadcb8f02e4a23f3250b24d179b0e9; http://hdl.handle.net/10713/10181
    ae974a485f413a2113503eed53cd6c53
    10.1085/jgp.201812274
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